Gene Symbol | Ncstn |
---|---|
Entrez Gene | 289231 |
Alt Symbol | - |
Species | Rat |
Gene Type | protein-coding |
Description | nicastrin |
Other Description | - |
Swissprots | Q8CGU6 Q8CH12 |
Accessions | EDL94675 EDL94676 Q8CGU6 AF510722 AAO15915 AY101378 AAM44078 BC074006 BC167747 AAI67747 FQ212793 XM_006250283 XP_006250345 XM_008769733 XP_008767955 XM_008769734 XP_008767956 XM_008769735 XP_008767957 NM_001034026 NM_001034027 NM_174864 NP_777353 |
Function | Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome {ECO:0000250}. |
Top Pathways | Notch signaling pathway, Alzheimer's disease |
Nicastrin Polyclonal Antibody Antibody - abx116869 from Abbexa
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NCSTN Antibody - CSB-PA015600GA01HU from Cusabio
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Nicastrin Antibody - abx130123 from Abbexa
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Nicastrin, Polyclonal Antibody - MBS2027868 from MyBioSource
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Nicastrin (NCSTN) Polyclonal Antibody - CAU23981 from Biomatik
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Nicastrin (NCSTN), Polyclonal Antibody - MBS2067525 from MyBioSource
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Nicastrin (NCSTN), Polyclonal Antibody - MBS2067526 from MyBioSource
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Nicastrin (NCSTN), Polyclonal Antibody - MBS2067527 from MyBioSource
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Nicastrin (NCSTN), Polyclonal Antibody - MBS2067528 from MyBioSource
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Nicastrin (NCSTN), Polyclonal Antibody - MBS2067529 from MyBioSource
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Nicastrin (NCSTN), Polyclonal Antibody - MBS2067530 from MyBioSource
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