Ncstn

Gene Symbol Ncstn
Entrez Gene 289231
Alt Symbol -
Species Rat
Gene Type protein-coding
Description nicastrin
Other Description -
Swissprots Q8CGU6 Q8CH12
Accessions EDL94675 EDL94676 Q8CGU6 AF510722 AAO15915 AY101378 AAM44078 BC074006 BC167747 AAI67747 FQ212793 XM_006250283 XP_006250345 XM_008769733 XP_008767955 XM_008769734 XP_008767956 XM_008769735 XP_008767957 NM_001034026 NM_001034027 NM_174864 NP_777353
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex (By similarity). {ECO:0000250}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome {ECO:0000250}.
Top Pathways Notch signaling pathway, Alzheimer's disease

CompoZr® Knockout ZFN Kit - CKOZFN57814 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND57814 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NCSTN siRNA (Rat) - CRR4028 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

shRNA set against Rat NCSTN (NM_174864.3) - SHH350248 from Creative biogene

Category siRNA
Species Reactivities Rat

shRNA set against Rat Ncstn(NM_174864.3) - SHR001542 from Creative biogene

Category siRNA
Species Reactivities Rat

Rat NCSTN siRNA - orb298877 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

NCSTN shRNA Plasmid (Rat) - CHR4028 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Rat

NCSTN miRNA 3'UTR clone - MiUTR1R-04139 from Creative biogene

Species Reactivities Rat
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