Gene Symbol | Ncstn |
---|---|
Entrez Gene | 289231 |
Alt Symbol | - |
Species | Rat |
Gene Type | protein-coding |
Description | nicastrin |
Other Description | - |
Swissprots | Q8CGU6 Q8CH12 |
Accessions | EDL94675 EDL94676 Q8CGU6 AF510722 AAO15915 AY101378 AAM44078 BC074006 BC167747 AAI67747 FQ212793 XM_006250283 XP_006250345 XM_008769733 XP_008767955 XM_008769734 XP_008767956 XM_008769735 XP_008767957 NM_001034026 NM_001034027 NM_174864 NP_777353 |
Function | Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome {ECO:0000250}. |
Top Pathways | Notch signaling pathway, Alzheimer's disease |
Recombinant Nicastrin (NCSTN) - RPC680Ra01 from Cloud-clone
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Recombinant Rat Nicastrin(Ncstn) - CSB-YP015600RA CSB-EP015600RA CSB-BP015600RA CSB-MP015600RA from Cusabio
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Nicastrin Protein (Recombinant) - abx167650 from Abbexa
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Recombinant Rat NCSTN Protein - NCSTN-3925R from Creative Biomart
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Recombinant Nicastrin (NCSTN) - RPU53602 from Biomatik
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NCSTN Recombinant Protein (OPCD05605) - OPCD05605 from Aviva Systems Biology
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Nicastrin (Ncstn), Recombinant Protein - MBS1304075 from MyBioSource
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