Nlrp3

Gene Symbol	Nlrp3
Entrez Gene	216799
Alt Symbol	AGTAVPRL, AII/AVP, Cias1, FCAS, FCU, MWS, Mmig1, NALP3, Pypaf1
Species	Mouse
Gene Type	protein-coding
Description	NLR family, pyrin domain containing 3
Other Description	NACHT, LRR and PYD domains-containing protein 3|NACHT/LRR/pyrin domain-containing protein 3|PYRIN-containing APAF1-like protein 1|cold autoinflammatory syndrome 1 homolog|cold autoinflammatory syndrome 1 protein homolog|cryopyrin|mast cell maturation inducible protein 1|mast cell maturation-associated-inducible protein 1
Swissprots	Q8R4B8 Q6JEL0 Q1JQ87 Q1JQ88
Accessions	AAR03541 AAR03542 AAR03543 Q8R4B8 AF486632 AAL90874 AY337285 AAR03540 AY355340 AAR14737 AY495376 AAS75794 AY495377 AAS75795 BC116174 AAI16175 BC116175 AAI16176 KF032621 AGU01502 XM_006532857 XP_006532920 XM_006532858 XP_006532921 XM_006532859 XP_006532922 XR_388400 NM_145827 NP_665826
Function	May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA (By similarity). Activates caspase-1 as part of the NALP3 inflammasome complex in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. {ECO:0000250, ECO:0000269|PubMed:16407888, ECO:0000269|PubMed:16407890, ECO:0000269|PubMed:16546100, ECO:0000269|PubMed:17008311}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:14688236}.
Tissue Specificity	Widely expressed with high levels in peripheral blood leukocytes. Not detected in thymus. {ECO:0000269|PubMed:15302403, ECO:0000269|PubMed:16546100}.
Top Pathways	NOD-like receptor signaling pathway, Pertussis, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

NACHT, LRR and PYD domains-containing protein 3 (NLRP3), Mouse, ELISA Kit - CSB-EL015871MO from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

NACHT, LRR and PYD domains-containing protein 3, Nlrp3, Mouse, ELISA Kit - E14531m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

NLR family, pyrin domain containing 3, ELISA Kit - MBS920134 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of mouse NLRP3 is typically less than 1.56 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 6.25 pg/ml -400 pg/ml.

Mouse NACHT, LRR and PYD domains-containing protein 3(NLRP3) ELISA kit - CSB-EL015871MO from Cusabio Category ELISA Kit Sensitivity 1.56 pg/ml Range 6.25 pg/ml-400 pg/ml

Mouse Nlrp3 ELISA Kit - E061055 from Biobool Category ELISA Kit

NLRP3 ELISA Kit (Mouse) (OKEH05486) - OKEH05486 from Aviva Systems Biology Category ELISA Kit Prices $440.00 Sizes 96 wells Sensitivity 0.16 ng/mL Range 0.312-20 ng/mL

NACHT, LRR and PYD domains-containing protein 3, ELISA Kit - MBS2884362 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NLRP3 (Nod Like Receptor Pyrins-3), ELISA Kit - MBS7606270 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/ml Range 0.313-20ng/ml

NLRP3 ELISA Kit (Mouse) (OKCA02415) - OKCA02415 from Aviva Systems Biology Category ELISA Kit Sensitivity 1.56 pg/mL Range 6.25 - 400 pg/mL

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