Gene Symbol | Nlrp3 |
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Entrez Gene | 216799 |
Alt Symbol | AGTAVPRL, AII/AVP, Cias1, FCAS, FCU, MWS, Mmig1, NALP3, Pypaf1 |
Species | Mouse |
Gene Type | protein-coding |
Description | NLR family, pyrin domain containing 3 |
Other Description | NACHT, LRR and PYD domains-containing protein 3|NACHT/LRR/pyrin domain-containing protein 3|PYRIN-containing APAF1-like protein 1|cold autoinflammatory syndrome 1 homolog|cold autoinflammatory syndrome 1 protein homolog|cryopyrin|mast cell maturation inducible protein 1|mast cell maturation-associated-inducible protein 1 |
Swissprots | Q8R4B8 Q6JEL0 Q1JQ87 Q1JQ88 |
Accessions | AAR03541 AAR03542 AAR03543 Q8R4B8 AF486632 AAL90874 AY337285 AAR03540 AY355340 AAR14737 AY495376 AAS75794 AY495377 AAS75795 BC116174 AAI16175 BC116175 AAI16176 KF032621 AGU01502 XM_006532857 XP_006532920 XM_006532858 XP_006532921 XM_006532859 XP_006532922 XR_388400 NM_145827 NP_665826 |
Function | May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA (By similarity). Activates caspase-1 as part of the NALP3 inflammasome complex in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. {ECO:0000250, ECO:0000269|PubMed:16407888, ECO:0000269|PubMed:16407890, ECO:0000269|PubMed:16546100, ECO:0000269|PubMed:17008311}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:14688236}. |
Tissue Specificity | Widely expressed with high levels in peripheral blood leukocytes. Not detected in thymus. {ECO:0000269|PubMed:15302403, ECO:0000269|PubMed:16546100}. |
Top Pathways | NOD-like receptor signaling pathway, Pertussis, Influenza A |
Cryopyrin CRISPR/Cas9 KO Plasmid (m) - sc-432122 from Santa Cruz Biotechnology
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Cryopyrin HDR Plasmid (m) - sc-432122-HDR from Santa Cruz Biotechnology
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Cryopyrin Double Nickase Plasmid (m) - sc-432122-NIC from Santa Cruz Biotechnology
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Cryopyrin Double Nickase Plasmid (m2) - sc-432122-NIC-2 from Santa Cruz Biotechnology
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Cryopyrin CRISPR Activation Plasmid (m) - sc-432122-ACT from Santa Cruz Biotechnology
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Cryopyrin CRISPR Activation Plasmid (m2) - sc-432122-ACT-2 from Santa Cruz Biotechnology
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Cryopyrin Lentiviral Activation Particles (m) - sc-432122-LAC from Santa Cruz Biotechnology
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Cryopyrin Lentiviral Activation Particles (m2) - sc-432122-LAC-2 from Santa Cruz Biotechnology
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Cryopyrin siRNA (m) - sc-45470 from Santa Cruz Biotechnology
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Cryopyrin shRNA Plasmid (m) - sc-45470-SH from Santa Cruz Biotechnology
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Cryopyrin shRNA (m) Lentiviral Particles - sc-45470-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN36510 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36510 from Sigma-Aldrich
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NLRP3 siRNA (Mouse) - CRN2059 from Cohesion Biosciences
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shRNA set against Mouse NLRP3 (NM_145827.3) - SHH352968 from Creative biogene
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shRNA set against Mouse Nlrp3(NM_145827.3) - SHG086797 from Creative biogene
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NLRP3 shRNA Plasmid (Mouse) - CHN2059 from Cohesion Biosciences
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NLRP3 miRNA 3'UTR clone - MiUTR1M-07688 from Creative biogene
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