Nlrp3

Gene Symbol Nlrp3
Entrez Gene 216799
Alt Symbol AGTAVPRL, AII/AVP, Cias1, FCAS, FCU, MWS, Mmig1, NALP3, Pypaf1
Species Mouse
Gene Type protein-coding
Description NLR family, pyrin domain containing 3
Other Description NACHT, LRR and PYD domains-containing protein 3|NACHT/LRR/pyrin domain-containing protein 3|PYRIN-containing APAF1-like protein 1|cold autoinflammatory syndrome 1 homolog|cold autoinflammatory syndrome 1 protein homolog|cryopyrin|mast cell maturation inducible protein 1|mast cell maturation-associated-inducible protein 1
Swissprots Q8R4B8 Q6JEL0 Q1JQ87 Q1JQ88
Accessions AAR03541 AAR03542 AAR03543 Q8R4B8 AF486632 AAL90874 AY337285 AAR03540 AY355340 AAR14737 AY495376 AAS75794 AY495377 AAS75795 BC116174 AAI16175 BC116175 AAI16176 KF032621 AGU01502 XM_006532857 XP_006532920 XM_006532858 XP_006532921 XM_006532859 XP_006532922 XR_388400 NM_145827 NP_665826
Function May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA (By similarity). Activates caspase-1 as part of the NALP3 inflammasome complex in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. {ECO:0000250, ECO:0000269|PubMed:16407888, ECO:0000269|PubMed:16407890, ECO:0000269|PubMed:16546100, ECO:0000269|PubMed:17008311}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:14688236}.
Tissue Specificity Widely expressed with high levels in peripheral blood leukocytes. Not detected in thymus. {ECO:0000269|PubMed:15302403, ECO:0000269|PubMed:16546100}.
Top Pathways NOD-like receptor signaling pathway, Pertussis, Influenza A

Recombinant Mouse NACHT, LRR and PYD domains-containing protein 3(Nlrp3) ,partia - CSB-YP823181MO CSB-EP823181MO CSB-BP823181MO CSB-MP823181MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Recombinant Mouse NLRP3 Protein - NLRP3-10722M from Creative Biomart

Category Protein
Source Mammalian Cells
Species Mouse

Nlrp3 Recombinant Protein (OPCA03354) - OPCA03354 from Aviva Systems Biology

Category Protein
Prices $365.00
Sizes 50 µg
Source Mouse

NLRP3 Recombinant Protein (OPCD05680) - OPCD05680 from Aviva Systems Biology

Category Protein
Source E.coli
Species Mouse

Recombinant Mouse NACHT, LRR and PYD domains-containing protein 3(Nlrp3),partial - AP74319 from Signalway Antibody

Category Protein
Prices $155.00, $390.00, $665.00, $1,090.00, $1,835.00, $2,915.00
Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg
Source E.coli
Species Mouse

NACHT, LRR and PYD domains-containing protein 3, Recombinant Protein - MBS1448454 from MyBioSource

Category Protein
Prices $255.00, $665.00, $895.00, $1,090.00, $1,120.00, $1,120.00, $1,295.00, $1,725.00, $1,755.00, $1,755.00, $1,755.00, $2,545.00
Sizes 50 µg (E-Coli), 200 µg (E-Coli), 50 µg (Baculovirus), 500 µg (E-Coli), 50 µg (Mammalian-Cell), 500 µg (Yeast), 100 µg (Baculovirus), 1 mg (E-Coli), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

NACHT, LRR and PYD domains-containing protein 3 (Nlrp3), Recombinant Protein - MBS9423899 from MyBioSource

Category Protein
Prices $200.00, $380.00, $610.00, $960.00, $1,570.00
Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg
Source E Coli
Species Mouse

Mouse Cryopyrin protein - orb358603 from Biorbyt

Category Protein
Species Mouse

Recombinant Mouse NLRP3 Protein, His-tagged - NLRP3-10722ME from Creative Biomart

Category Protein
Source E. coli
Species Mouse
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