| Gene Symbol |
Nlrp3
|
| Entrez Gene |
216799
|
| Alt Symbol |
AGTAVPRL, AII/AVP, Cias1, FCAS, FCU, MWS, Mmig1, NALP3, Pypaf1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
NLR family, pyrin domain containing 3
|
| Other Description |
NACHT, LRR and PYD domains-containing protein 3|NACHT/LRR/pyrin domain-containing protein 3|PYRIN-containing APAF1-like protein 1|cold autoinflammatory syndrome 1 homolog|cold autoinflammatory syndrome 1 protein homolog|cryopyrin|mast cell maturation inducible protein 1|mast cell maturation-associated-inducible protein 1
|
| Swissprots |
Q8R4B8 Q6JEL0 Q1JQ87 Q1JQ88
|
| Accessions |
AAR03541 AAR03542 AAR03543 Q8R4B8 AF486632 AAL90874 AY337285 AAR03540 AY355340 AAR14737 AY495376 AAS75794 AY495377 AAS75795 BC116174 AAI16175 BC116175 AAI16176 KF032621 AGU01502 XM_006532857 XP_006532920 XM_006532858 XP_006532921 XM_006532859 XP_006532922 XR_388400 NM_145827 NP_665826
|
| Function |
May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA (By similarity). Activates caspase-1 as part of the NALP3 inflammasome complex in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. {ECO:0000250, ECO:0000269|PubMed:16407888, ECO:0000269|PubMed:16407890, ECO:0000269|PubMed:16546100, ECO:0000269|PubMed:17008311}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:14688236}.
|
| Tissue Specificity |
Widely expressed with high levels in peripheral blood leukocytes. Not detected in thymus. {ECO:0000269|PubMed:15302403, ECO:0000269|PubMed:16546100}.
|
| Top Pathways |
NOD-like receptor signaling pathway, Pertussis, Influenza A
|