Gene Symbol | Itga2b |
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Entrez Gene | 16399 |
Alt Symbol | AI172977, CD41, CD41B, GpIIb, alphaIIb |
Species | Mouse |
Gene Type | protein-coding |
Description | integrin alpha 2b |
Other Description | GP IIb|GPalpha IIb|alpha IIb|integrin alpha-IIb|platelet glycoprotein IIb of IIb/II Ia complex|platelet membrane glycoprotein IIb |
Swissprots | Q3U3R7 Q9QUM0 Q9Z2M0 Q64229 |
Accessions | AAF06996 EDL34136 Q9QUM0 AF045019 AAD02339 AF166384 AAF43997 AF170316 AAD56216 AK048700 BAC33425 AK140749 AK142289 BAE25013 AK154619 BAE32718 AK156872 AK157012 AK158443 AK161727 BC120493 AAI20494 BC137570 AAI37571 BY204133 S43388 AAB23054 NM_010575 NP_034705 |
Function | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Top Pathways | Hypertrophic cardiomyopathy (HCM), Rap1 signaling pathway, PI3K-Akt signaling pathway, Dilated cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
Integrin αIIb (MWReg30) - sc-19963 from Santa Cruz Biotechnology
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Anti-CD41 antibody [MW Reg 30] (Biotin) - ab95727 from Abcam
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Anti-CD41 antibody [MWReg30] - ab33661 from Abcam
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Anti-CD41 antibody [MWReg30] - ab191099 from Abcam
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Anti-CD41 antibody [MWReg30] (Allophycocyanin) - ab95725 from Abcam
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Anti-CD41 antibody [MWReg30] (PE/Cy7 ®) - ab95726 from Abcam
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Anti-CD41 antibody [MWReg30] (Phycoerythrin) - ab33660 from Abcam
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Anti-CD41 antibody [MWReg30] - Low endotoxin, Azide free - ab171210 from Abcam
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Integrin alpha 2b/CD41 Antibody (386629) [Unconjugated] - MAB41181 from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (386627) - MAB4118 from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (MWReg30) - NBP1-43415 from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (386629) [Phycoerythrin] - FAB41181P from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (MWReg30) [Biotin] - NBP1-43649 from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (MWReg30) [Allophycocyanin] - NBP1-43415APC from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (MWReg30) [PE] - NBP1-43415PE from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (MWReg30) [DyLight 350] - NBP1-43415UV from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (MWReg30) [DyLight 680] - NBP1-43415FR from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (MWReg30) [7C] - NBP1-43415V2 from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (MWReg30) [Alexa Fluor (R) 700] - NBP1-43415AF700 from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (MWReg30) [Alexa Fluor (R) 647] - NBP1-43415AF647 from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (MWReg30) [Alexa Fluor (R) 488] - NBP1-43415AF488 from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (MWReg30) [Alexa Fluor (R) 405] - NBP1-43415AF405 from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (MWReg30) [DyLight 405] - NBP1-43415V from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (MWReg30) [PerCP] - NBP1-43415PCP from Novus Biologicals
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Integrin alpha 2b/CD41 Antibody (MWReg30) [DyLight 488] - NBP1-43415G from Novus Biologicals
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