Gene Symbol | Itga2b |
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Entrez Gene | 16399 |
Alt Symbol | AI172977, CD41, CD41B, GpIIb, alphaIIb |
Species | Mouse |
Gene Type | protein-coding |
Description | integrin alpha 2b |
Other Description | GP IIb|GPalpha IIb|alpha IIb|integrin alpha-IIb|platelet glycoprotein IIb of IIb/II Ia complex|platelet membrane glycoprotein IIb |
Swissprots | Q3U3R7 Q9QUM0 Q9Z2M0 Q64229 |
Accessions | AAF06996 EDL34136 Q9QUM0 AF045019 AAD02339 AF166384 AAF43997 AF170316 AAD56216 AK048700 BAC33425 AK140749 AK142289 BAE25013 AK154619 BAE32718 AK156872 AK157012 AK158443 AK161727 BC120493 AAI20494 BC137570 AAI37571 BY204133 S43388 AAB23054 NM_010575 NP_034705 |
Function | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Top Pathways | Hypertrophic cardiomyopathy (HCM), Rap1 signaling pathway, PI3K-Akt signaling pathway, Dilated cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
Integrin αIIb CRISPR/Cas9 KO Plasmid (m) - sc-421160 from Santa Cruz Biotechnology
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Integrin αIIb HDR Plasmid (m) - sc-421160-HDR from Santa Cruz Biotechnology
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Integrin αIIb Double Nickase Plasmid (m) - sc-421160-NIC from Santa Cruz Biotechnology
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Integrin αIIb Double Nickase Plasmid (m2) - sc-421160-NIC-2 from Santa Cruz Biotechnology
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Integrin αIIb CRISPR Activation Plasmid (m) - sc-421160-ACT from Santa Cruz Biotechnology
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Integrin αIIb CRISPR Activation Plasmid (m2) - sc-421160-ACT-2 from Santa Cruz Biotechnology
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Integrin αIIb Lentiviral Activation Particles (m) - sc-421160-LAC from Santa Cruz Biotechnology
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Integrin αIIb Lentiviral Activation Particles (m2) - sc-421160-LAC-2 from Santa Cruz Biotechnology
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Integrin αIIb siRNA (m) - sc-45927 from Santa Cruz Biotechnology
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Integrin αIIb shRNA Plasmid (m) - sc-45927-SH from Santa Cruz Biotechnology
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Integrin αIIb shRNA (m) Lentiviral Particles - sc-45927-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN33984 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33984 from Sigma-Aldrich
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ITGA2B siRNA (Mouse) - CRM2110 from Cohesion Biosciences
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ITGA2B - MBS8214836 from MyBioSource
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shRNA set against Mouse ITGA2B (NM_010575.2) - SHH321177 from Creative biogene
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shRNA set against Mouse Itga2b(NM_010575.2) - SHL181324 from Creative biogene
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Integrin αIIb CRISPR/Cas9 KO Plasmid (m2) - sc-421160-KO-2 from Santa Cruz Biotechnology
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Integrin αIIb HDR Plasmid (m2) - sc-421160-HDR-2 from Santa Cruz Biotechnology
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Mouse ITGA2B siRNA - orb281586 from Biorbyt
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ITGA2B shRNA Plasmid (Mouse) - CHM2110 from Cohesion Biosciences
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ITGA2B miRNA 3'UTR clone - MiUTR1M-06132 from Creative biogene
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