Itga2b

Gene Symbol	Itga2b
Entrez Gene	16399
Alt Symbol	AI172977, CD41, CD41B, GpIIb, alphaIIb
Species	Mouse
Gene Type	protein-coding
Description	integrin alpha 2b
Other Description	GP IIb|GPalpha IIb|alpha IIb|integrin alpha-IIb|platelet glycoprotein IIb of IIb/II Ia complex|platelet membrane glycoprotein IIb
Swissprots	Q3U3R7 Q9QUM0 Q9Z2M0 Q64229
Accessions	AAF06996 EDL34136 Q9QUM0 AF045019 AAD02339 AF166384 AAF43997 AF170316 AAD56216 AK048700 BAC33425 AK140749 AK142289 BAE25013 AK154619 BAE32718 AK156872 AK157012 AK158443 AK161727 BC120493 AAI20494 BC137570 AAI37571 BY204133 S43388 AAB23054 NM_010575 NP_034705
Function	Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Top Pathways	Hypertrophic cardiomyopathy (HCM), Rap1 signaling pathway, PI3K-Akt signaling pathway, Dilated cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mouse ITGA2B Gene cDNA Clone - orb171681 from Biorbyt Prices $519.00 Sizes 10 μg Species Mouse

Mouse Itga2b ORF Clone(NM_010575.2) - CDCR249243 from Creative Biomart Species Mouse Accession NM_010575.2

Mouse Itga2b ORF Clone(NM_010575.2) - CDCR249244 from Creative Biomart Species Mouse Accession NM_010575.2

Mouse ITGA2B/CD41 Gene ORF cDNA clone in cloning vector - MG51294-G from Sino Biological Species Mouse

Mouse ITGA2B/CD41 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - MG51294-ACR from Sino Biological Species Mouse

Mouse ITGA2B/CD41 Gene ORF cDNA clone expression plasmid, C-HA tag - MG51294-CY from Sino Biological Species Mouse

Mouse ITGA2B/CD41 Gene ORF cDNA clone expression plasmid, N-Flag tag - MG51294-NF from Sino Biological Species Mouse

Mouse ITGA2B/CD41 Gene ORF cDNA clone expression plasmid, C-His tag - MG51294-CH from Sino Biological Species Mouse

Mouse ITGA2B/CD41 Gene ORF cDNA clone expression plasmid, N-HA tag - MG51294-NY from Sino Biological Species Mouse

Mouse ITGA2B/CD41 Gene ORF cDNA clone expression plasmid, N-His tag - MG51294-NH from Sino Biological Species Mouse

Mouse ITGA2B/CD41 Gene ORF cDNA clone expression plasmid, C-Flag tag - MG51294-CF from Sino Biological Species Mouse

Mouse ITGA2B/CD41 Gene ORF cDNA clone expression plasmid, N-Myc tag - MG51294-NM from Sino Biological Species Mouse

Mouse ITGA2B/CD41 Gene ORF cDNA clone expression plasmid, C-Myc tag - MG51294-CM from Sino Biological Species Mouse

Mouse ITGA2B/CD41 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - MG51294-ACG from Sino Biological Species Mouse

Mouse ITGA2B/CD41 Gene ORF cDNA clone expression plasmid - MG51294-UT from Sino Biological Species Mouse

Human Itga2b ORF clone (NM_010575.2) - CDCL121869 from Creative biogene Species Mouse

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