| Gene Symbol |
Itga2b
|
| Entrez Gene |
16399
|
| Alt Symbol |
AI172977, CD41, CD41B, GpIIb, alphaIIb
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
integrin alpha 2b
|
| Other Description |
GP IIb|GPalpha IIb|alpha IIb|integrin alpha-IIb|platelet glycoprotein IIb of IIb/II Ia complex|platelet membrane glycoprotein IIb
|
| Swissprots |
Q3U3R7 Q9QUM0 Q9Z2M0 Q64229
|
| Accessions |
AAF06996 EDL34136 Q9QUM0 AF045019 AAD02339 AF166384 AAF43997 AF170316 AAD56216 AK048700 BAC33425 AK140749 AK142289 BAE25013 AK154619 BAE32718 AK156872 AK157012 AK158443 AK161727 BC120493 AAI20494 BC137570 AAI37571 BY204133 S43388 AAB23054 NM_010575 NP_034705
|
| Function |
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Hypertrophic cardiomyopathy (HCM), Rap1 signaling pathway, PI3K-Akt signaling pathway, Dilated cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC)
|