Gene Symbol | Smad1 |
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Entrez Gene | 17125 |
Alt Symbol | AI528653, Madh1, Madr1, Mlp1, MusMLP |
Species | Mouse |
Gene Type | protein-coding |
Description | SMAD family member 1 |
Other Description | MAD homolog 1|Smad 1|dwarfin-A|dwf-A|mMad1|mad-related protein 1|mothers against DPP homolog 1|mothers against decapentaplegic homolog 1|mothers-against-DPP-related 1 |
Swissprots | Q9CYK6 P70442 Q6GT95 P70340 |
Accessions | AAG41407 EDL10873 P70340 AK017583 BAB30820 AK034045 BAC28558 AK054104 BAC35658 AK084505 BAC39200 AK087692 BAC39970 AK158509 BC058693 AAH58693 U58992 AAC52785 U74359 AAB18256 XM_006530746 XP_006530809 NM_008539 NP_032565 |
Function | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). {ECO:0000250, ECO:0000269|PubMed:15329343}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4. Colocalizes with LEMD3 at the nucleus inner membrane (By similarity). {ECO:0000250}. |
Tissue Specificity | Ubiquitous. |
Top Pathways | TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer |
Smad1 CRISPR/Cas9 KO Plasmid (m) - sc-421524 from Santa Cruz Biotechnology
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Smad1 HDR Plasmid (m) - sc-421524-HDR from Santa Cruz Biotechnology
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Smad1 Double Nickase Plasmid (m) - sc-421524-NIC from Santa Cruz Biotechnology
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Smad1 Double Nickase Plasmid (m2) - sc-421524-NIC-2 from Santa Cruz Biotechnology
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Smad1 CRISPR Activation Plasmid (m) - sc-421524-ACT from Santa Cruz Biotechnology
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Smad1 CRISPR Activation Plasmid (m2) - sc-421524-ACT-2 from Santa Cruz Biotechnology
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Smad1 Lentiviral Activation Particles (m) - sc-421524-LAC from Santa Cruz Biotechnology
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Smad1 Lentiviral Activation Particles (m2) - sc-421524-LAC-2 from Santa Cruz Biotechnology
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Smad1 siRNA (m) - sc-36507 from Santa Cruz Biotechnology
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Smad1 shRNA Plasmid (m) - sc-36507-SH from Santa Cruz Biotechnology
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Smad1 shRNA (m) Lentiviral Particles - sc-36507-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN41639 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND41639 from Sigma-Aldrich
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SMAD1 siRNA (Mouse) - CRM2433 from Cohesion Biosciences
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SMAD1 - MBS8208226 from MyBioSource
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shRNA set against Mouse Smad1 (NM_008539.3) - SHH412952 from Creative biogene
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shRNA set against Mouse Smad1(NM_008539.3) - SHL015056 from Creative biogene
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Mouse SMAD1 siRNA - orb281909 from Biorbyt
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SMAD1 shRNA Plasmid (Mouse) - CHM2433 from Cohesion Biosciences
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SMAD1 miRNA 3'UTR clone - MiUTR1M-10975 from Creative biogene
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