Ifnl2

Gene Symbol Ifnl2
Entrez Gene 330496
Alt Symbol EG330496, IL-28A, Il28a
Species Mouse
Gene Type protein-coding
Description interferon lambda 2
Other Description IFN-lambda-2|IFN-lambda2|IL-28A|interferon lambda-2|interferon-lambda2|interleukin 28A|interleukin-28A
Swissprots Q4VK74 E9Q2S2
Accessions CAI75185 CAJ41830 CAL33804 CAS97666 CAT02304 CBY45350 CBY45410 Q4VK74 AY869695 AAX58714 BC150796 AAI50797 XM_006540121 XP_006540184 NM_001024673 NP_001019844
Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express
Subcellular Location Secreted {ECO:0000250|UniProtKB:Q8IZJ0}.
Top Pathways Jak-STAT signaling pathway

IL-28 (A-3) - sc-137207 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-28 (A-3): sc-137207. Western blot analysis of truncated mouse recombinant IL-28.

IL-28 (E-15) - sc-46373 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IL-28 (D-12) - sc-137151 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-28 (D-12): sc-137151. Western blot analysis of truncated mouse recombinant IL-28.

IL-28 (M-180) - sc-66934 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-28 (M-180): sc-66934. Western blot analysis of mouse recombinant IL-28.

IL-28 (N-14) - sc-46377 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IL-28A/IFN-lambda 2 Antibody - AF4635 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Recombinant Mouse IL‑28A (Catalog # 4635‑ML) reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the HepG2 human hepatocellular carcinoma cell line in a dose-dependent manner (orange line). Inhibition of EMCV activity elicited by Recombinant Mouse IL‑28A (20 ng/mL) is neutralized (green line) by increasing concentrations of Sheep Anti‑Mouse IL‑28A Antigen Affinity‑purified Polyclonal Antibody (Catalog # AF4635). The ND50 is typically 3‑15 µg/mL.

IL-28A/IFN-lambda 2 Antibody (9T12) - NBP2-21959 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 9T12

IL-28A/IFN-lambda 2 Antibody [Biotin] - BAF4635 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal

IL-28A/B (IFN-lambda 2/3) Antibody (244707) [Biotin] - BAM17891 from Novus Biologicals

Prices $389.00
Sizes 250 µg
Host Rat
Clonality Monoclonal
Clone 244707

IL-28A antibody - GTX51540 from GeneTex

Prices $289.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Anti-IL-28A antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX51540

IL28A antibody [9T12] - GTX53430 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rat
Clonality Monoclonal
Clone 9T12

Anti -IL-28A (Interleukin-28A) - 216615 from USBiological Life Science

Host Rat
Clonality Monoclonal
Clone 14L519

Polyclonal Antibody to Interleukin 28A (IL28A) - PAB689Mu01 from Cloud-clone

Host Rabbit
Clonality Polyclonal

Polyclonal Antibody to Interleukin 28A (IL28A) - PAB689Mu02 from Cloud-clone

Host Rabbit
Clonality Polyclonal

IL28A antibody - 70R-51218 from Fitzgerald

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

IL-28A / IL28A Antibody, Rabbit PAb, Antigen Affinity Purified - 51305-T16-50 from Sino Biological

Prices $99.00, $99.00, $99.00
Sizes 50 µg, 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal

IL-28A / IL28A Antibody, Rabbit PAb - 51305-RP01-400 from Sino Biological

Prices $99.00, $99.00
Sizes 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal

IL-28A antibody - orb361462 from Biorbyt

Prices $323.00, $442.00, $570.00
Sizes 100 μg, 200 μg, 400 μg
Host Rabbit
Clonality Polyclonal

IL-28A / IL28A Antibody, Rabbit PAb, Antigen Affinity Purified - 51305-T16-200 from Sino Biological

Host Rabbit
Clonality Polyclonal

Recombinant Rat Anti-Ifnl2 Antibody (CBL811) - NEUT-1056CQ from Creative Biolabs

Host Rat
Clone CBL811
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