| Gene Symbol |
Ifnl2
|
| Entrez Gene |
330496
|
| Alt Symbol |
EG330496, IL-28A, Il28a
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
interferon lambda 2
|
| Other Description |
IFN-lambda-2|IFN-lambda2|IL-28A|interferon lambda-2|interferon-lambda2|interleukin 28A|interleukin-28A
|
| Swissprots |
Q4VK74 E9Q2S2
|
| Accessions |
CAI75185 CAJ41830 CAL33804 CAS97666 CAT02304 CBY45350 CBY45410 Q4VK74 AY869695 AAX58714 BC150796 AAI50797 XM_006540121 XP_006540184 NM_001024673 NP_001019844
|
| Function |
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express
|
| Subcellular Location |
Secreted {ECO:0000250|UniProtKB:Q8IZJ0}.
|
| Top Pathways |
Jak-STAT signaling pathway
|