Ifnl2

Gene Symbol	Ifnl2
Entrez Gene	330496
Alt Symbol	EG330496, IL-28A, Il28a
Species	Mouse
Gene Type	protein-coding
Description	interferon lambda 2
Other Description	IFN-lambda-2|IFN-lambda2|IL-28A|interferon lambda-2|interferon-lambda2|interleukin 28A|interleukin-28A
Swissprots	Q4VK74 E9Q2S2
Accessions	CAI75185 CAJ41830 CAL33804 CAS97666 CAT02304 CBY45350 CBY45410 Q4VK74 AY869695 AAX58714 BC150796 AAI50797 XM_006540121 XP_006540184 NM_001024673 NP_001019844
Function	Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express
Subcellular Location	Secreted {ECO:0000250|UniProtKB:Q8IZJ0}.
Top Pathways	Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Mouse IL-28A/IFN-lambda 2 Protein - NBP2-35074 from Novus Biologicals Category Protein Prices $69.00, $169.00, $2,669.00 Sizes 5 µg, 20 µg, 1 mg Source E. coli

IL28A Recombinant Protein (Active) - GTX47964-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source E. coli Species Mouse

Recombinant Mouse IL-28A/IFN-lambda 2 - 4635-ML-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Asp20-Val193, with a C-terminal 6-His tag

Recombinant Mouse IL-28A/IFN-lambda 2, CF - 4635-ML-025/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Asp20-Val193, with a C-terminal 6-His tag

Mouse IL28A (His Tag) protein - orb179655 from Biorbyt Category Protein Prices $221.00, $434.00 Sizes 20 μg, 50 μg Source Human Cells Species Mouse

Murine IFN-lambda 2 protein - orb223871 from Biorbyt Category Protein Prices $221.00, $357.00, $553.00, $910.00 Sizes 5 μg, 20 μg, 100 μg, 250 μg Species Mouse

IFN lambda 2 protein (Mouse) - 30R-AI130 from Fitzgerald Category Protein Prices $225.00 Sizes 20 µg Source E.coli Species Mouse

Interleukin-28A / IL28A - PA279 from Acris Antibodies Category Protein Prices $135.00 Sizes 5 µg Source E. coli Species Mouse

Interleukin-28A / IL28A - PA279X from Acris Antibodies Category Protein Prices $235.00 Sizes 20 µg Source E. coli Species Mouse

Interleukin-28A / IL28A - P6007 from Acris Antibodies Category Protein Prices $370.00 Sizes 20 µg Species Mouse

IFN lambda 2 Recombinant Protein - 40-444 from ProSci Category Protein Prices $150.00, $250.00 Sizes 5 µg, 20 µg Source E. coli Species Mouse

IL 28A Mouse - CYPS-748 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Mouse

Recombinant Mouse Ifnl2, His-tagged - Ifnl2-511M from Creative Biomart Category Protein Source Human Cells Species Mouse

Recombinant Mouse Ifnl2, His-tagged - Ifnl2-645M from Creative Biomart Category Protein Source NSO cells Species Mouse

Recombinant Mouse Interleukin 28a - Il28a-229M from Creative Biomart Category Protein Source NSO Cells .

Recombinant Murine Interleukin 28A - II28A-992M from Creative Biomart Category Protein Source E.coli .

Mouse IFNL2 / IL28A Protein (His Tag) - 51305-M08H-50 from Sino Biological Category Protein Prices $108.00, $198.00 Sizes 20 µg, 50 µg Source Human Cells Species Mouse

Recombinant Interleukin 28A (IL28A) - RPB689Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Interleukin 28A (IL28A) - RPB689Mu02 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse Interleukin-28A(Il28a) - CSB-YP703302MO CSB-EP703302MO CSB-BP703302MO CSB-MP703302MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Recombinant Mouse IL-28A/IFN-lambda 2 Protein - 4635-ML from R&D Systems Category Protein Prices $319.00 Sizes 25 µg Source Mouse myeloma cell line, NS0-derived Asp20-Val193, with a C-terminal 6-His tag Species Mouse

Recombinant Mouse IL-28A/IFN-lambda 2 Protein, CF - 4635-ML/CF from R&D Systems Category Protein Prices $319.00 Sizes 25 µg Source Mouse myeloma cell line, NS0-derived Asp20-Val193, with a C-terminal 6-His tag Species Mouse

Interleukin-28A / IL28A - TP723167 from Acris Antibodies Category Protein Prices $199.00 Sizes 20 µg Source E. coli Species Mouse

Recombinant Mouse IL-28A/IFN-lambda 2 - CRI020B from Cell Science Prices $235.00 Sizes 20 μg Species Mouse

Recombinant Mouse IL-28A/IFN-lambda 2 - CRI020A from Cell Science Prices $135.00 Sizes 5 μg Species Mouse

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