Ifnl2

Gene Symbol	Ifnl2
Entrez Gene	330496
Alt Symbol	EG330496, IL-28A, Il28a
Species	Mouse
Gene Type	protein-coding
Description	interferon lambda 2
Other Description	IFN-lambda-2|IFN-lambda2|IL-28A|interferon lambda-2|interferon-lambda2|interleukin 28A|interleukin-28A
Swissprots	Q4VK74 E9Q2S2
Accessions	CAI75185 CAJ41830 CAL33804 CAS97666 CAT02304 CBY45350 CBY45410 Q4VK74 AY869695 AAX58714 BC150796 AAI50797 XM_006540121 XP_006540184 NM_001024673 NP_001019844
Function	Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express
Subcellular Location	Secreted {ECO:0000250|UniProtKB:Q8IZJ0}.
Top Pathways	Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IL-28 ELISA Kit (Mouse) : 96 Wells (OKAG00187) - OKAG00187 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 32 pg/mL Range 32-4,000 pg/mL

Interleukin 28A (IL-28A), Mouse, ELISA Kit - CSB-E17651m from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Interleukin 28A (IL28A), Mouse, ELISA Kit - SEB689Mu from ARP American Research Products Category ELISA Kit Prices $704.00 Sizes 96 t Sensitivity 6.3pg/mL Range 15.6-1,000pg/mL

Interleukin-28A, Il28a, Mouse, ELISA Kit - E1689m from ARP American Research Products Category ELISA Kit Prices $496.00 Sizes 96 t Range 31.2-2000 pg/mL

Interleukin 28A (IL28A), Mouse, CLIA Kit - SCB689Mu from ARP American Research Products Category CLIA Kit Prices $864.00 Sizes 96 t Sensitivity 4.9pg/mL Range 15.6-1,000pg/mL

Mouse IL-28 ELISA - ELM-IL28 from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 2 pg/ml Range 2 pg/ml - 600 pg/ml

IL-28 (Murine) OmniKine™ ELISA Kit - OK-0291 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range 32-4000 pg/ml

Interleukin 28A (IL28A), ELISA Kit - MBS2023651 from MyBioSource Category ELISA Kit Prices $370.00, $550.00, $750.00, $3,065.00, $5,550.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of IL28A is typically less than 5.8pg/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 15.6-1, 000pg/mL

Interleukin 28A, IL-28A/IFN-lambda2, ELISA Kit - MBS9304753 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse Interleukin 28A(IL-28A) ELISA Kit - CSB-E17651m from Cusabio Category ELISA Kit Sensitivity 1.95 pg/ml Range 7.8 pg/ml-500 pg/ml

ELISA Kit for Interleukin 28A (IL28A) - SEB689Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 5.8pg/mL. Range 15.625-1000pg/mL The standard curve concentrations used for the ELISA's were 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.625pg/mL

CLIA Kit for Interleukin 28A (IL28A) - SCB689Mu from Cloud-clone Category CLIA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.62pg/mL. Range 1.372-1000pg/mL The standard curve concentrations used for the ELISA's were 1000pg/mL, 333.33pg/mL, 111.11pg/mL, 37.04pg/mL, 12.346pg/mL, 4.115pg/mL, 1.372pg/mL

Interleukin 28A (IL-28A) , ELISA Kit - MBS930535 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of mouse IL-28A is typically less than 1.95 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 7.81 pg/ml-500 pg/ml.

Mouse Interleukin 28A (IL28A) ELISA Kit - EKU05310 from Biomatik Category ELISA Kit Prices $718.00, $3,196.00, $5,817.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 5.8 pg/mL Range 15.62-1000 pg/mL

Mouse Interleukin 28A ELISA Kit - abx154250 from Abbexa Category ELISA Kit Range 15.63 pg/ml - 1000 pg/ml

Mouse Interleukin 28A CLIA Kit - abx190526 from Abbexa Category CLIA Kit Range 1.37 pg/ml - 1000 pg/ml

Interleukin 28A (IL28A), Mouse, ELISA Kit - DL-IL28A-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 15.6-1,000 pg/mL

Interleukin 28A (IL28A), CLIA Kit - MBS2000927 from MyBioSource Category CLIA Kit Prices $450.00, $670.00, $925.00, $3,805.00, $6,855.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of this kit is typically less than 0.62pg/mL. Range 1.37-1000pg/mL

IL-28 (Murine) LumiAb™ ELISA Kit - Lum-8291 from Assay Biotechnology Category ELISA Kit Prices $400.00, $800.00, $1,200.00 Sizes 1 kit, 2 kits, 3 kits Range 8-500

Mouse IL28A ELISA Kit - abx574962 from Abbexa Category ELISA Kit Sensitivity 6.3 pg/ml Range 15.625 pg/ml - 1000 pg/ml

Mouse Interleukin 28A (IL28A) ELISA Kit (CLIA) - EKU72276 from Biomatik Category ELISA Kit Prices $907.20, $3,991.68, $7,257.60 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.62pg/mL Range 1.37-1000pg/mL The standard curve concentrations used for the CLIA’s were 1000pg/mL, 333.33pg/mL, 111.11pg/mL, 37.04pg/mL, 12.35pg/mL, 4.12pg/mL, 1.37pg/mL

Mouse Interleukin 28A(IL-28A) ELISA Kit - EKC37165 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,287.50 Sizes 96 t, 5x96t, 10x96t Sensitivity 1.95 pg/ml Range 500 pg/ml-7.81 pg/ml

Mouse Interleukin-28A ELISA Kit - EKE51451 from Biomatik Category ELISA Kit Prices $570.40, $2,424.20, $4,563.20 Sizes 96 t, 5x96t, 10x96t Range 31.2-2000 pg/mL

Il28a ELISA Kit (Mouse) : 96 Wells (OKEH02796) - OKEH02796 from Aviva Systems Biology Category ELISA Kit Prices $360.00 Sizes 96 wells Sensitivity < 20 pg/mL Range 31.2 - 2,000 pg/mL

Mouse IL-28 ELISA - ELM-IL28-1 from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,560.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

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