Ifnl2

Gene Symbol Ifnl2
Entrez Gene 330496
Alt Symbol EG330496, IL-28A, Il28a
Species Mouse
Gene Type protein-coding
Description interferon lambda 2
Other Description IFN-lambda-2|IFN-lambda2|IL-28A|interferon lambda-2|interferon-lambda2|interleukin 28A|interleukin-28A
Swissprots Q4VK74 E9Q2S2
Accessions CAI75185 CAJ41830 CAL33804 CAS97666 CAT02304 CBY45350 CBY45410 Q4VK74 AY869695 AAX58714 BC150796 AAI50797 XM_006540121 XP_006540184 NM_001024673 NP_001019844
Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express
Subcellular Location Secreted {ECO:0000250|UniProtKB:Q8IZJ0}.
Top Pathways Jak-STAT signaling pathway

Il-28a siRNA (m) - sc-146218 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Il-28a shRNA Plasmid (m) - sc-146218-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Il-28a shRNA (m) Lentiviral Particles - sc-146218-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU195471 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN33788 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33788 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

IFNL2 siRNA (Mouse) - CRN4647 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

IFNL2 - MBS829055 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

Il-28a CRISPR/Cas9 KOPlasmid (m) - sc-437298 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Il-28a HDR Plasmid (m) - sc-437298-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Il-28a Double Nickase Plasmid (m) - sc-437298-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Il-28a Double Nickase Plasmid (m2) - sc-437298-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Il-28a CRISPR Activation Plasmid (m) - sc-437298-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Il-28a CRISPR Activation Plasmid (m2) - sc-437298-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Il-28a Lentiviral Activation Particles (m) - sc-437298-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Il-28a Lentiviral Activation Particles (m2) - sc-437298-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

shRNA set against Mouse IL28A (NM_001024673.2) - SHH318829 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse IFNL2 siRNA - orb294122 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

IFNL2 shRNA Plasmid (Mouse) - CHN4647 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

IL28A miRNA 3'UTR clone - MiUTR1M-04216 from Creative biogene

Species Reactivities Mouse
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