SAE1

Gene Symbol	SAE1
Entrez Gene	10055
Alt Symbol	AOS1, HSPC140, SUA1, UBLE1A
Species	Human
Gene Type	protein-coding
Description	SUMO1 activating enzyme subunit 1
Other Description	SUMO-1 activating enzyme E1 N subunit|SUMO-1 activating enzyme subunit 1|SUMO-activating enzyme subunit 1|activator of SUMO1|sentrin/SUMO-activating protein AOS1|ubiquitin-like 1-activating enzyme E1A|ubiquitin-like protein SUMO-1 activating enzyme
Swissprots	G3XAK6 Q9UBE0 O95717 B2RDP5 Q9P020 F5GXX7 B3KMQ2
Accessions	EAW57460 EAW57461 EAW57462 EAW57463 EAW57464 Q9UBE0 AF046025 AAD23902 AF090385 AAD12785 AF110956 AAD24433 AF161489 AAF29104 AI339364 AK021978 BAG51064 AK027595 BAG51356 AK055481 AK090645 AK302287 BAG63628 AK315624 BAG37992 BC000344 AAH00344 BC003611 AAH03611 BC018271 AAH18271 BC128518 BC128519 BT007290 AAP35954 CN386158 DA047601 DA086973 DC297573 DC312737 DQ891751 ABM82677 DQ894932 ABM85858 XM_006722963 XP_006723026 XM_006722965 XP_006723028 XM_011526305 XP_011524607 NM_001145713 NP_001139185 NM_001145714 NP_001139186 NM_005500 NP_005491 NR_027280
Function	The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:10187858, ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:11481243}.
Tissue Specificity	Expression level increases during S phase and drops in G2 phase (at protein level). {ECO:0000269|PubMed:11481243}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat SAE1 ELISA Kit (Cell-Based ELISA) - LS-F1798 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Human SAE1 ELISA Kit (Sandwich ELISA) - LS-F12555 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

SUMO-activating enzyme subunit 1, SAE1, Human, ELISA Kit - E3292h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

SAE1 (Human) Matched Antibody Pair - H00010055-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

SAE1 (Human) Matched Antibody Pair - H00010055-AP21 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

AOS1 Colorimetric Cell-Based ELISA Kit - CB5042 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

SUMO1 activating enzyme subunit 1, ELISA Kit - MBS9341431 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.5ng/ml-16ng/ml.

Mouse SAE1 ELISA Kit (Custom ELISA) - LS-F19865 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Bovine SAE1 ELISA Kit (Custom ELISA) - LS-F19866 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Rat SAE1 ELISA Kit (Custom ELISA) - LS-F19864 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human SUMO-activating enzyme subunit 1 ELISA Kit - abx251614 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human SUMO-activating enzyme subunit 1 ELISA Kit - EKE54189 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.078 ng/mL Range 0.156-10 ng/mL

SAE1 - EKH4532 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

SAE1 ELISA Kit (Human) (OKEH01703) - OKEH01703 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.078 ng/mL Range 0.156 - 10 ng/mL

Human SAE1 ELISA Kit - E036911 from Biobool Category ELISA Kit Sensitivity <0.094ng/ml

Human SUMO-activating enzyme subunit 1 ELISA Kit - EK4587 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.19ng/mL Range 0.312-20 ng/mL.

anti-SAE1 / AOS1 antibody - ARG63368 from Arigo Biolaboratories Category ELISA Kit

SUMO-Activating Enzyme Subunit 1 (SAE1), ELISA Kit - MBS9345577 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 1 (SAE1), ELISA Kit - MBS9358920 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 1 (SAE1), ELISA Kit - MBS9367485 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 1 (SAE1), ELISA Kit - MBS9348112 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 1 (SAE1), ELISA Kit - MBS9343693 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 1 (SAE1), ELISA Kit - MBS9353615 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 1 (SAE1), ELISA Kit - MBS9352893 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 1 (SAE1), ELISA Kit - MBS9356786 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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