SAE1

Gene Symbol	SAE1
Entrez Gene	10055
Alt Symbol	AOS1, HSPC140, SUA1, UBLE1A
Species	Human
Gene Type	protein-coding
Description	SUMO1 activating enzyme subunit 1
Other Description	SUMO-1 activating enzyme E1 N subunit|SUMO-1 activating enzyme subunit 1|SUMO-activating enzyme subunit 1|activator of SUMO1|sentrin/SUMO-activating protein AOS1|ubiquitin-like 1-activating enzyme E1A|ubiquitin-like protein SUMO-1 activating enzyme
Swissprots	G3XAK6 Q9UBE0 O95717 B2RDP5 Q9P020 F5GXX7 B3KMQ2
Accessions	EAW57460 EAW57461 EAW57462 EAW57463 EAW57464 Q9UBE0 AF046025 AAD23902 AF090385 AAD12785 AF110956 AAD24433 AF161489 AAF29104 AI339364 AK021978 BAG51064 AK027595 BAG51356 AK055481 AK090645 AK302287 BAG63628 AK315624 BAG37992 BC000344 AAH00344 BC003611 AAH03611 BC018271 AAH18271 BC128518 BC128519 BT007290 AAP35954 CN386158 DA047601 DA086973 DC297573 DC312737 DQ891751 ABM82677 DQ894932 ABM85858 XM_006722963 XP_006723026 XM_006722965 XP_006723028 XM_011526305 XP_011524607 NM_001145713 NP_001139185 NM_001145714 NP_001139186 NM_005500 NP_005491 NR_027280
Function	The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:10187858, ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:11481243}.
Tissue Specificity	Expression level increases during S phase and drops in G2 phase (at protein level). {ECO:0000269|PubMed:11481243}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SAE1-Over-expression-Lysate - LY10831a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

SAE1 293T Cell Transient Overexpression Lysate(Denatured) - H00010055-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SAE1 overexpression lysate - LY428977 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SAE1 293 Cell Lysate - 401516 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SUMO Activating Enzyme E1 (SAE1) Overexpression Lysate (Denatured) - H00010055-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

SUMO Activating Enzyme E1 (SAE1) Overexpression Lysate (Native) - NBL1-15677 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

AOS-1 (h): 293 Lysate - sc-112313 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

AOS-1 (h): 293T Lysate - sc-176690 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

AOS-1 (h2): 293T Lysate - sc-159151 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

SAE1 Over-expression Lysate Product - GWB-BF5238 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human SAE1 Insect Cell Lysate (WB positive control) - 13921-HNCBL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human SAE1 Insect Cell Lysate (WB positive control) - 13921-H20BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

SUMO Activating Enzyme E1 (SAE1) Overexpression Lysate (Native) - NBP2-09877 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SUMO Activating Enzyme E1 (SAE1) Overexpression Lysate (Denatured) - H00010055-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Human SAE1 Baculovirus-Insect Cells Transfected Lysate Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175270 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human SAE1 Baculovirus-Insect Cells Transfected Lysate Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175223 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human SAE1 Knockdown Stable Cell Line - CSC-DC013750 from Creative biogene Category Cell Line Species Human

Search more