SAE1

Gene Symbol	SAE1
Entrez Gene	10055
Alt Symbol	AOS1, HSPC140, SUA1, UBLE1A
Species	Human
Gene Type	protein-coding
Description	SUMO1 activating enzyme subunit 1
Other Description	SUMO-1 activating enzyme E1 N subunit|SUMO-1 activating enzyme subunit 1|SUMO-activating enzyme subunit 1|activator of SUMO1|sentrin/SUMO-activating protein AOS1|ubiquitin-like 1-activating enzyme E1A|ubiquitin-like protein SUMO-1 activating enzyme
Swissprots	G3XAK6 Q9UBE0 O95717 B2RDP5 Q9P020 F5GXX7 B3KMQ2
Accessions	EAW57460 EAW57461 EAW57462 EAW57463 EAW57464 Q9UBE0 AF046025 AAD23902 AF090385 AAD12785 AF110956 AAD24433 AF161489 AAF29104 AI339364 AK021978 BAG51064 AK027595 BAG51356 AK055481 AK090645 AK302287 BAG63628 AK315624 BAG37992 BC000344 AAH00344 BC003611 AAH03611 BC018271 AAH18271 BC128518 BC128519 BT007290 AAP35954 CN386158 DA047601 DA086973 DC297573 DC312737 DQ891751 ABM82677 DQ894932 ABM85858 XM_006722963 XP_006723026 XM_006722965 XP_006723028 XM_011526305 XP_011524607 NM_001145713 NP_001139185 NM_001145714 NP_001139186 NM_005500 NP_005491 NR_027280
Function	The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:10187858, ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:11481243}.
Tissue Specificity	Expression level increases during S phase and drops in G2 phase (at protein level). {ECO:0000269|PubMed:11481243}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AOS1+UBA2 full length protein - ab3804 from Abcam Category Protein Prices $345.00 Sizes 15 µg Source Baculovirus

AOS1+UBA2 protein (Human) - Chemical Free - ab80730 from Abcam Category Protein Prices $253.00 Sizes 25 µg Source E. coli Species Human

Human SAE1 full length protein - ab140413 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human SAE1 full length protein - ab96772 from Abcam Category Protein Source E. coli Species Human

Human SAE1 peptide - ab23106 from Abcam Category Peptide Species Human

Human SAE1/SAE2 full length protein - ab157088 from Abcam Category Protein Source E. coli Species Human

SAE1 Antibody Blocking Peptide - LS-E25600 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SAE1 Antibody Blocking Peptide - LS-E30925 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SAE1 Antibody Blocking Peptide - LS-E18694 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SAE1 Antibody Blocking Peptide - LS-E18695 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SAE1 Antibody Blocking Peptide - LS-E6974 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SUMO Activating Enzyme E1 (SAE1) Recombinant Protein - H00010055-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SUMO Activating Enzyme E1 (SAE1) Recombinant Protein - H00010055-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SUMO Activating Enzyme E1 (SAE1) Protein - NBP1-45275 from Novus Biologicals Category Protein Prices $309.00 Sizes 50 µg Species Human

SUMO Activating Enzyme E1 (SAE1) Peptide - NBP1-76262PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

SAE1-AOS1-Antibody-C-term-Blocking-peptide - BP2511b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SAE1 blocking peptide - GTX25645-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Bovine

Recombinant Human SUMO E1 (SAE1/UBA2), CF - E-315-025 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Yeast GST-SUMO E1 (SAE1/UBA2), CF - E-310-050 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal GST (glutathione S-transferase) tag

Recombinant Yeast SUMO E1 (SAE1/UBA2), CF - E-311-025 from R&D Systems Category Protein Source E. coli-derived,

SAE1 Protein (OPPA02375) - OPPA02375 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human SAE1 protein (GST Tag) - orb139624 from Biorbyt Category Protein Prices $323.00, $400.00, $612.00 Sizes 20 μg, 50 μg, 100 μg Source Baculovirus-Insect Cells Species Human

Human SUMO1 Activating Enzyme Subunit 1 protein - orb90261 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 2 μg, 10 μg Source E.coli Species Human

Human SAE1 protein - orb139625 from Biorbyt Category Protein Prices $238.00, $400.00 Sizes 20 μg, 50 μg Source Baculovirus-Insect Cells Species Human

SAE1 Immunizing peptide - orb16949 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

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