SAE1

Gene Symbol	SAE1
Entrez Gene	10055
Alt Symbol	AOS1, HSPC140, SUA1, UBLE1A
Species	Human
Gene Type	protein-coding
Description	SUMO1 activating enzyme subunit 1
Other Description	SUMO-1 activating enzyme E1 N subunit|SUMO-1 activating enzyme subunit 1|SUMO-activating enzyme subunit 1|activator of SUMO1|sentrin/SUMO-activating protein AOS1|ubiquitin-like 1-activating enzyme E1A|ubiquitin-like protein SUMO-1 activating enzyme
Swissprots	G3XAK6 Q9UBE0 O95717 B2RDP5 Q9P020 F5GXX7 B3KMQ2
Accessions	EAW57460 EAW57461 EAW57462 EAW57463 EAW57464 Q9UBE0 AF046025 AAD23902 AF090385 AAD12785 AF110956 AAD24433 AF161489 AAF29104 AI339364 AK021978 BAG51064 AK027595 BAG51356 AK055481 AK090645 AK302287 BAG63628 AK315624 BAG37992 BC000344 AAH00344 BC003611 AAH03611 BC018271 AAH18271 BC128518 BC128519 BT007290 AAP35954 CN386158 DA047601 DA086973 DC297573 DC312737 DQ891751 ABM82677 DQ894932 ABM85858 XM_006722963 XP_006723026 XM_006722965 XP_006723028 XM_011526305 XP_011524607 NM_001145713 NP_001139185 NM_001145714 NP_001139186 NM_005500 NP_005491 NR_027280
Function	The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:10187858, ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:11481243}.
Tissue Specificity	Expression level increases during S phase and drops in G2 phase (at protein level). {ECO:0000269|PubMed:11481243}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-SAE1-cDNA-Clone - DC00151 from Abgent, a WuXi AppTec company Prices $467.10 Sizes 10 µg Species Human Accession BC000344

SAE1 - MBS1266350 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC000344

Human SAE1 cDNA clone(NM_001145713.1) - CDFH016869 from Creative Biomart Species Human Accession NM_001145713.1

Human SAE1 cDNA clone(NM_001145714.1) - CDFH016870 from Creative Biomart Species Human Accession NM_001145714.1

Human SAE1 ORF Clone(NM_001145713.1) - CDCR353013 from Creative Biomart Species Human Accession NM_001145713.1

Human SAE1 ORF Clone(NM_001145714.1) - CDCR353014 from Creative Biomart Species Human Accession NM_001145714.1

Human SAE1 ORF Clone(NM_001145714.1) - CDCR353015 from Creative Biomart Species Human Accession NM_001145714.1

Human SAE1 ORF Clone(NM_001145713.1) - CDCR353019 from Creative Biomart Species Human Accession NM_001145713.1

Human SAE1 Gene ORF cDNA clone in cloning vector - HG13921-G from Sino Biological Species Human

Human SAE1 Gene ORF cDNA clone expression plasmid, C-His tag - HG13921-CH from Sino Biological Species Human

Human SAE1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13921-NF from Sino Biological Species Human

Human SAE1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13921-NY from Sino Biological Species Human

Human SAE1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13921-NM from Sino Biological Species Human

Human SAE1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13921-CF from Sino Biological Species Human

Human SAE1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13921-CM from Sino Biological Species Human

Human SAE1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG13921-ANG from Sino Biological Species Human

Human SAE1 Gene ORF cDNA clone expression plasmid - HG13921-UT from Sino Biological Species Human

Human SAE1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13921-CY from Sino Biological Species Human

Human SAE1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13921-ACG from Sino Biological Species Human

Human SAE1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13921-ACR from Sino Biological Species Human

Human SAE1 Gene ORF cDNA clone expression plasmid, N-His tag - HG13921-NH from Sino Biological Species Human

Human SAE1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG13921-ANR from Sino Biological Species Human

human SAE1 ORF clone (NM_001145713.1) - CDCH076676 from Creative biogene Species Human

human SAE1 ORF clone (NM_001145714.1) - CDCH076678 from Creative biogene Species Human

human SAE1 ORF clone (NM_005500.2) - CDCH076680 from Creative biogene Species Human

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