Ccnd1

Gene Symbol Ccnd1
Entrez Gene 12443
Alt Symbol AI327039, CycD1, Cyl-1, PRAD1, bcl-1, cD1
Species Mouse
Gene Type protein-coding
Description cyclin D1
Other Description G1/S-specific cyclin-D1
Swissprots P25322
Accessions AAF23491 AAO13813 EDL18282 EDL18283 P25322 AK005352 AK017834 AK053348 BAC35355 AK149905 BAE29157 AK164997 BAE37996 AK169905 AK170833 BAE42061 BC044841 AAH44841 BC060172 BY089102 EU600170 ACC78286 M64403 AAA37502 S78355 AAB34495 XM_011241977 XP_011240279 NM_007631 NP_031657
Function Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:19767775}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Cyclin D- CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
Top Pathways Acute myeloid leukemia, Cell cycle, Prolactin signaling pathway, MicroRNAs in cancer, Bladder cancer

CD1 (M-276) - sc-9161 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CD1 (M-276): sc-9161. Western blot analysis of CD1 expression in mouse liver (A) and rat liver (B) tissue extracts.

CD1 (Q-19) - sc-7093 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD1 (Q-19): sc-7093. Western blot analysis of CD1 expression in mouse liver tissue extract.

Cyclin D1 Polyclonal Antibody - bs-0623R from Bioss

Prices $279.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human placenta tissue labeled with Anti-Cyclin D1 Polyclonal Antibody, Unconjugated (bs-0623R) at 1:200, followed by conjugation to the secondary antibody and DAB staining

Cyclin D1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-0623R-A350 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Cyclin D1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-0623R-A488 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Cyclin D1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-0623R-A555 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Cyclin D1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-0623R-A647 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Cyclin D1 Polyclonal Antibody, Cy3 Conjugated - bs-0623R-Cy3 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Cyclin D1 Polyclonal Antibody, Cy5 Conjugated - bs-0623R-Cy5 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Cyclin D1 Polyclonal Antibody, Cy5.5 Conjugated - bs-0623R-Cy5.5 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Cyclin D1 Polyclonal Antibody, Cy7 Conjugated - bs-0623R-Cy7 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Cyclin D1 Polyclonal Antibody, FITC Conjugated - bs-0623R-FITC from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Cyclin D1 Polyclonal Antibody, Biotin Conjugated - bs-0623R-Biotin from Bioss

Prices $359.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Cyclin D1 Polyclonal Antibody, HRP Conjugated - bs-0623R-HRP from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CCND1 antibody produced in rabbit - SAB2106484 from Sigma-Aldrich

Prices $341.00, $341.00
Sizes 50 µg, 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CCND1: <B>Cat. No. SAB2106484</B>: Western blot analysis of Ccnd1 with Ccnd1 9cyclin D1) antibody against the C terminal of Ccnd1 (50 μg) antibody at 1.0 μg/mL.

Ccnd1 antibody - C-terminal region (ARP39777_P050) - ARP39777_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CCND1 Antibody (OABF00225) - OABF00225 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Cyclin D1 antibody - 10R-2414 from Fitzgerald

Prices $125.00
Sizes 5 ml
Host Mouse
Clonality Monoclonal
Clone DCS-6

Cyclin D1 antibody - 10R-2363 from Fitzgerald

Prices $215.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone DCS-6

Cyclin D1 antibody (Thr286) - 70R-30874 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti -Cyclin D1 - C8454-09 from USBiological Life Science

Host Mouse
Clonality Monoclonal
Clone 3G115

Anti -Cyclin D1 - C8454-01C from USBiological Life Science

Host Mouse
Clonality Monoclonal
Clone 4H320
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