Gene Symbol | Ccnd1 |
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Entrez Gene | 12443 |
Alt Symbol | AI327039, CycD1, Cyl-1, PRAD1, bcl-1, cD1 |
Species | Mouse |
Gene Type | protein-coding |
Description | cyclin D1 |
Other Description | G1/S-specific cyclin-D1 |
Swissprots | P25322 |
Accessions | AAF23491 AAO13813 EDL18282 EDL18283 P25322 AK005352 AK017834 AK053348 BAC35355 AK149905 BAE29157 AK164997 BAE37996 AK169905 AK170833 BAE42061 BC044841 AAH44841 BC060172 BY089102 EU600170 ACC78286 M64403 AAA37502 S78355 AAB34495 XM_011241977 XP_011240279 NM_007631 NP_031657 |
Function | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19767775}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Cyclin D- CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. |
Top Pathways | Acute myeloid leukemia, Cell cycle, Prolactin signaling pathway, MicroRNAs in cancer, Bladder cancer |
CD1 (M-276) - sc-9161 from Santa Cruz Biotechnology
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CD1 (Q-19) - sc-7093 from Santa Cruz Biotechnology
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Cyclin D1 Polyclonal Antibody - bs-0623R from Bioss
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Cyclin D1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-0623R-A350 from Bioss
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Cyclin D1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-0623R-A488 from Bioss
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Cyclin D1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-0623R-A555 from Bioss
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Cyclin D1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-0623R-A647 from Bioss
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Cyclin D1 Polyclonal Antibody, Cy3 Conjugated - bs-0623R-Cy3 from Bioss
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Cyclin D1 Polyclonal Antibody, Cy5 Conjugated - bs-0623R-Cy5 from Bioss
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Cyclin D1 Polyclonal Antibody, Cy5.5 Conjugated - bs-0623R-Cy5.5 from Bioss
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Cyclin D1 Polyclonal Antibody, Cy7 Conjugated - bs-0623R-Cy7 from Bioss
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Cyclin D1 Polyclonal Antibody, FITC Conjugated - bs-0623R-FITC from Bioss
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Cyclin D1 Polyclonal Antibody, Biotin Conjugated - bs-0623R-Biotin from Bioss
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Cyclin D1 Polyclonal Antibody, HRP Conjugated - bs-0623R-HRP from Bioss
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Anti-CCND1 antibody produced in rabbit - SAB2106484 from Sigma-Aldrich
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Ccnd1 antibody - C-terminal region (ARP39777_P050) - ARP39777_P050 from Aviva Systems Biology
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CCND1 Antibody (OABF00225) - OABF00225 from Aviva Systems Biology
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Cyclin D1 antibody - 10R-2414 from Fitzgerald
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Cyclin D1 antibody - 10R-2363 from Fitzgerald
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Cyclin D1 antibody (Thr286) - 70R-30874 from Fitzgerald
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Anti -CCND1 (BCL1, Cyl-1, D11S287E, PRAD1, U21B31, parathyroid adenomatosis 1, B CellCLL/lymphoma 1, G1/S-specific cyclin D1) - 144297 from USBiological Life Science
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Anti -Cyclin D1 - C8454-09 from USBiological Life Science
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Anti -Cyclin D1 - C8454-01C from USBiological Life Science
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Anti -Cyclin D1 (G1/S-specific Cyclin-D1, B Cell Lymphoma 1 Protein, BCL-1, BCL-1Oncogene, PRAD1 Oncogene, CCND1, BCL1, PRAD1) - 139965 from USBiological Life Science
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Anti -Cyclin D1 (G1/S-specific Cyclin-D1, B Cell Lymphoma 1 Protein, BCL-1, BCL-1Oncogene, PRAD1 Oncogene, CCND1, BCL1, PRAD1) (AP) - 139965-AP from USBiological Life Science
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