| Gene Symbol | Ccnd1 |
|---|---|
| Entrez Gene | 12443 |
| Alt Symbol | AI327039, CycD1, Cyl-1, PRAD1, bcl-1, cD1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | cyclin D1 |
| Other Description | G1/S-specific cyclin-D1 |
| Swissprots | P25322 |
| Accessions | AAF23491 AAO13813 EDL18282 EDL18283 P25322 AK005352 AK017834 AK053348 BAC35355 AK149905 BAE29157 AK164997 BAE37996 AK169905 AK170833 BAE42061 BC044841 AAH44841 BC060172 BY089102 EU600170 ACC78286 M64403 AAA37502 S78355 AAB34495 XM_011241977 XP_011240279 NM_007631 NP_031657 |
| Function | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:19767775}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Cyclin D- CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. |
| Top Pathways | Acute myeloid leukemia, Cell cycle, Prolactin signaling pathway, MicroRNAs in cancer, Bladder cancer |