Ccnd1

Gene Symbol	Ccnd1
Entrez Gene	12443
Alt Symbol	AI327039, CycD1, Cyl-1, PRAD1, bcl-1, cD1
Species	Mouse
Gene Type	protein-coding
Description	cyclin D1
Other Description	G1/S-specific cyclin-D1
Swissprots	P25322
Accessions	AAF23491 AAO13813 EDL18282 EDL18283 P25322 AK005352 AK017834 AK053348 BAC35355 AK149905 BAE29157 AK164997 BAE37996 AK169905 AK170833 BAE42061 BC044841 AAH44841 BC060172 BY089102 EU600170 ACC78286 M64403 AAA37502 S78355 AAB34495 XM_011241977 XP_011240279 NM_007631 NP_031657
Function	Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:19767775}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Cyclin D- CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
Top Pathways	Acute myeloid leukemia, Cell cycle, Prolactin signaling pathway, MicroRNAs in cancer, Bladder cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

SignalSilence ® Cyclin D1 siRNA I (Mouse Specific) - 6423 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Mouse

SignalSilence ® Cyclin D1 siRNA II (Mouse Specific) - 6477 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Mouse

cyclin D1 CRISPR/Cas9 KO Plasmid (m) - sc-419509 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

cyclin D1 HDR Plasmid (m) - sc-419509-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

cyclin D1 Double Nickase Plasmid (m) - sc-419509-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

cyclin D1 Double Nickase Plasmid (m2) - sc-419509-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

cyclin D1 CRISPR Activation Plasmid (m) - sc-419509-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

cyclin D1 CRISPR Activation Plasmid (m2) - sc-419509-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

cyclin D1 Lentiviral Activation Particles (m) - sc-419509-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

cyclin D1 Lentiviral Activation Particles (m2) - sc-419509-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

cyclin D1 siRNA (m) - sc-29287 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

cyclin D1 shRNA Plasmid (m) - sc-29287-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

cyclin D1 shRNA (m) Lentiviral Particles - sc-29287-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU036931 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN28256 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28256 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CCND1 siRNA (Mouse) - CRM0549 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

CCND1 - MBS8237196 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

shRNA set against Mouse CCND1 (NM_007631.2) - SHH257837 from Creative biogene Category siRNA Species Reactivities Mouse

shRNA set against Mouse Ccnd1(NM_007631.2) - SHG151957 from Creative biogene Category siRNA Species Reactivities Mouse

Mouse CCND1 siRNA - orb280025 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

CCND1 shRNA Plasmid (Mouse) - CHM0549 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

CCND1 miRNA 3'UTR clone - MiUTR1M-02685 from Creative biogene Species Reactivities Mouse

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