Gene Symbol | Nol3 |
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Entrez Gene | 78688 |
Alt Symbol | ARC, B430311C09Rik, MYC, NOP, Nop30 |
Species | Mouse |
Gene Type | protein-coding |
Description | nucleolar protein 3 (apoptosis repressor with CARD domain) |
Other Description | apoptosis repressor with CARD|nucleolar protein 3 |
Swissprots | Q9D1X0 |
Accessions | EDL11261 Q9D1X0 AK021023 BAB32281 AK053846 BAC35554 AK079536 BAC37674 AK197583 AY459322 AAR22550 BC027290 AAH27290 BC053971 XM_006531503 XP_006531566 NM_030152 NP_084428 |
Function | Apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:16505176) (PubMed:24312627). Inhibits calcium-mediated cell death by functionning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (By similarity). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mito |
Subcellular Location | Cytoplasm {ECO:0000250|UniProtKB:O60936, ECO:0000250|UniProtKB:Q62881}. Mitochondrion {ECO:0000250|UniProtKB:Q62881}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q62881}. Note=Phosphorylation at Thr-149 results in translocation to mithochondria. Colocalized with mitochondria in response to oxidative stress. {ECO:0000250|UniProtKB:Q62881}. |
Myc antibody - 70R-31557 from Fitzgerald
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cMyc antibody (Thr58) - 70R-34286 from Fitzgerald
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Myc antibody - 70R-37476 from Fitzgerald
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ARC antibody - 70R-31103 from Fitzgerald
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cMyc antibody (Thr358) - 70R-34284 from Fitzgerald
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cMyc antibody - 70R-34282 from Fitzgerald
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cMyc antibody - 70R-34287 from Fitzgerald
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cMyc antibody - 70R-34285 from Fitzgerald
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Myc antibody (Ser373) - 70R-37118 from Fitzgerald
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cMyc antibody - 70R-34283 from Fitzgerald
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MYC Antibody - abx104354 from Abbexa
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Rabbit Anti-Human ARC (N-term.) - 129-10031 from RayBiotech
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Anti-V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) - 20-3717 from ARP American Research Products
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c-myc Antibody - TGB-355 from Reagent Proteins
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Myc Antibody - TGB-337 from Reagent Proteins
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Myc-HRP Antibody - TGB-339 from Reagent Proteins
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Arc - 156 011 from Synaptic Systems
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Arc - 156 002 from Synaptic Systems
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Arc - 156 003 from Synaptic Systems
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Arc - 156 004 from Synaptic Systems
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Arc - 156 005 from Synaptic Systems
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Anti-Nop30 Antibody - ABC845 from EMD Millipore
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Nop30 antibody - 70R-50659 from Fitzgerald
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Mouse Anti c-Myc mAb (9E10) - MYC-MMYCc from ACROBiosystems
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Anti-Nop30 Antibody - ABC845 from Sigma-Aldrich
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