| Gene Symbol |
Nol3
|
| Entrez Gene |
78688
|
| Alt Symbol |
ARC, B430311C09Rik, MYC, NOP, Nop30
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
nucleolar protein 3 (apoptosis repressor with CARD domain)
|
| Other Description |
apoptosis repressor with CARD|nucleolar protein 3
|
| Swissprots |
Q9D1X0
|
| Accessions |
EDL11261 Q9D1X0 AK021023 BAB32281 AK053846 BAC35554 AK079536 BAC37674 AK197583 AY459322 AAR22550 BC027290 AAH27290 BC053971 XM_006531503 XP_006531566 NM_030152 NP_084428
|
| Function |
Apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:16505176) (PubMed:24312627). Inhibits calcium-mediated cell death by functionning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (By similarity). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mito
|
| Subcellular Location |
Cytoplasm {ECO:0000250|UniProtKB:O60936, ECO:0000250|UniProtKB:Q62881}. Mitochondrion {ECO:0000250|UniProtKB:Q62881}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q62881}. Note=Phosphorylation at Thr-149 results in translocation to mithochondria. Colocalized with mitochondria in response to oxidative stress. {ECO:0000250|UniProtKB:Q62881}.
|