Nol3
| Gene Symbol | Nol3 |
|---|---|
| Entrez Gene | 78688 |
| Alt Symbol | ARC, B430311C09Rik, MYC, NOP, Nop30 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | nucleolar protein 3 (apoptosis repressor with CARD domain) |
| Other Description | apoptosis repressor with CARD|nucleolar protein 3 |
| Swissprots | Q9D1X0 |
| Accessions | EDL11261 Q9D1X0 AK021023 BAB32281 AK053846 BAC35554 AK079536 BAC37674 AK197583 AY459322 AAR22550 BC027290 AAH27290 BC053971 XM_006531503 XP_006531566 NM_030152 NP_084428 |
| Function | Apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:16505176) (PubMed:24312627). Inhibits calcium-mediated cell death by functionning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (By similarity). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mito |
| Subcellular Location | Cytoplasm {ECO:0000250|UniProtKB:O60936, ECO:0000250|UniProtKB:Q62881}. Mitochondrion {ECO:0000250|UniProtKB:Q62881}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q62881}. Note=Phosphorylation at Thr-149 results in translocation to mithochondria. Colocalized with mitochondria in response to oxidative stress. {ECO:0000250|UniProtKB:Q62881}. |
Activity Regulated Cytoskeleton Associated Protein (ARC), Mouse, ELISA Kit - SEJ620Mu from ARP American Research Products
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Activity-regulated cytoskeleton-associated protein (ARC), Mouse, ELISA Kit - E03A1623 from ARP American Research Products
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Activity-regulated cytoskeleton-associated protein, Arc, Mouse, ELISA Kit - E7736m from ARP American Research Products
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Myc proto-oncogene protein (MYC), Mouse, ELISA Kit - E03M0410 from ARP American Research Products
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Myc proto-oncogene protein, Myc, Mouse, ELISA Kit - E1290m from ARP American Research Products
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V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC), Mouse, ELISA Kit - SEB290Mu from ARP American Research Products
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nucleolar protein 3 (apoptosis repressor with CARD domain) , ELISA Kit - MBS9329307 from MyBioSource
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Mouse MYC(Myc proto-oncogene protein) ELISA Kit - E-EL-M0376 from Elabscience
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Mouse MYC(Myc proto-oncogene protein) ELISA Kit - E-EL-M0376 from Iwai North America Inc.
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Mouse ARC ELISA Kit - abx153670 from Abbexa
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Mouse MYC ELISA Kit - abx154421 from Abbexa
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Activity Regulated Cytoskeleton Associated Protein (ARC), Mouse, ELISA Kit - DL-ARC-Mu from ARP American Research Products
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V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC), Mouse, ELISA Kit - DL-MYC-Mu from ARP American Research Products
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c-myc Oncogene Product, c-myc, Mouse, ELISA Kit - E-EL-M0376 from ARP American Research Products
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Mouse ARC ELISA Kit - abx570950 from Abbexa
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Mouse MYC ELISA Kit - abx571326 from Abbexa
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Mouse Arc ELISA Kit - E042655 from Biobool
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Mouse Myc ELISA Kit - E060652 from Biobool
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Mouse Nol3 ELISA Kit - E061999 from Biobool
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