Nol3

Gene Symbol Nol3
Entrez Gene 78688
Alt Symbol ARC, B430311C09Rik, MYC, NOP, Nop30
Species Mouse
Gene Type protein-coding
Description nucleolar protein 3 (apoptosis repressor with CARD domain)
Other Description apoptosis repressor with CARD|nucleolar protein 3
Swissprots Q9D1X0
Accessions EDL11261 Q9D1X0 AK021023 BAB32281 AK053846 BAC35554 AK079536 BAC37674 AK197583 AY459322 AAR22550 BC027290 AAH27290 BC053971 XM_006531503 XP_006531566 NM_030152 NP_084428
Function Apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:16505176) (PubMed:24312627). Inhibits calcium-mediated cell death by functionning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (By similarity). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mito
Subcellular Location Cytoplasm {ECO:0000250|UniProtKB:O60936, ECO:0000250|UniProtKB:Q62881}. Mitochondrion {ECO:0000250|UniProtKB:Q62881}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q62881}. Note=Phosphorylation at Thr-149 results in translocation to mithochondria. Colocalized with mitochondria in response to oxidative stress. {ECO:0000250|UniProtKB:Q62881}.

Recombinant Mouse Nucleolar protein 3(Nol3) - CSB-YP875187MO CSB-EP875187MO CSB-BP875187MO CSB-MP875187MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Mouse MYC protein - orb257703 from Biorbyt

Category Protein
Prices $400.00, $1,241.00
Sizes 100 μg, 1 mg
Species Mouse

Nucleolar protein 3 (Nol3), Recombinant Protein - MBS1354958 from MyBioSource

Category Protein
Prices $970.00, $970.00, $1,195.00, $1,195.00, $1,460.00, $1,460.00, $1,925.00, $1,925.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse
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