FGF2

Gene Symbol	FGF2
Entrez Gene	2247
Alt Symbol	BFGF, FGF-2, FGFB, HBGF-2
Species	Human
Gene Type	protein-coding
Description	fibroblast growth factor 2 (basic)
Other Description	basic fibroblast growth factor bFGF|fibroblast growth factor 2|heparin-binding growth factor 2|prostatropin
Swissprots	Q9UCS6 Q9UCS5 P09038 O00527 P78443 Q16443 Q7KZ11 Q7KZ72 A4LBB8 Q5PY50 Q9UC54
Accessions	AAB21432 ABO43041 ADL14514 CAA28027 CAA28028 CAA28029 CAA73868 EAX05222 P09038 AA256481 AB451321 BAG70135 AB451450 BAG70264 AY820133 AAV70487 BC111737 BC166646 AAI66646 BE439775 BP292299 BU501243 CN315083 J04513 AAA52531 M17599 AAA52534 M27968 AAA52448 S47380 AAD13853 NM_002006 NP_001997
Function	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. {ECO:0000269|PubMed:1721615, ECO:0000269|PubMed:8663044}.
Subcellular Location	Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.
Tissue Specificity	Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. {ECO:0000269|PubMed:1417798, ECO:0000269|PubMed:1721615}.
Top Pathways	Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active cow FGF basic full length protein - ab129471 from Abcam Category Protein Prices $302.00 Sizes 50 µg Source E. coli Species Bovine

Active cow FGF basic full length protein - ab73238 from Abcam Category Protein Source E. coli Species Bovine

Active cow FGF basic protein fragment - ab61845 from Abcam Category Protein Prices $200.00, $1,089.00 Sizes 50 µg, 500 µg Source E. coli Species Bovine

Active human FGF basic full length protein - ab9596 from Abcam Category Protein Prices $110.00, $257.00 Sizes 10 µg, 50 µg Source E. coli Species Human

Active human FGF basic full length protein - ab138337 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source Hordeum vulgare Species Human

Active human FGF basic full length protein - ab155734 from Abcam Category Protein Prices $239.00 Sizes 200 µg Source E. coli Species Human

Active human FGF basic full length protein - ab176058 from Abcam Category Protein Prices $110.00, $342.00 Sizes 10 µg, 50 µg Source E. coli Species Human

Active human FGF basic full length protein - ab88394 from Abcam Category Protein Prices $410.00 Sizes 5 µg Source HEK 293 cells Species Human

Active human FGF basic full length protein - ab192160 from Abcam Category Protein Prices $192.00 Sizes 50 µg Source E. coli Species Human

Active human FGF basic protein fragment - ab80215 from Abcam Category Protein Prices $257.00 Sizes 20 µg Source E. coli Species Human

Active human FGF2 full length protein - ab179489 from Abcam Category Protein Prices $202.00, $1,200.00 Sizes 50 µg, 500 µg Source E. coli Species Human

Active human FGF2 full length protein - ab179490 from Abcam Category Protein Prices $202.00, $797.00 Sizes 50 µg, 500 µg Source E. coli Species Human

Active mouse FGF basic full length protein - ab198563 from Abcam Category Protein Prices $300.00, $1,089.00 Sizes 50 µg, 500 µg Source E. coli Species Mouse

Active mouse FGF basic full length protein - ab192138 from Abcam Category Protein Prices $192.00 Sizes 50 µg Source E. coli Species Mouse

Active mouse FGF basic protein fragment - ab200265 from Abcam Category Protein Prices $101.00 Sizes 10 µg Source E. coli Species Mouse

Active mouse FGF2 full length protein - ab129033 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Mouse

Active rat FGF basic full length protein - ab64442 from Abcam Category Protein Prices $110.00, $368.00 Sizes 10 µg, 50 µg Source E. coli Species Rat

Active rat FGF basic full length protein - ab192114 from Abcam Category Protein Prices $192.00 Sizes 50 µg Source E. coli Species Rat

Active rat FGF2 full length protein - ab179499 from Abcam Category Protein Prices $202.00, $1,200.00 Sizes 50 µg, 500 µg Source E. coli Species Rat

Active rat FGF2 full length protein - ab200240 from Abcam Category Protein Prices $101.00 Sizes 10 µg Source E. coli Species Rat

FGF2 peptide - ab134425 from Abcam Category Peptide Prices $176.00 Sizes 1 ml

Human FGF basic full length protein - ab82116 from Abcam Category Protein Source Baculovirus Species Human

Mouse FGF basic protein fragment - ab50235 from Abcam Category Protein Source E. coli Species Mouse

FGF2 / Basic FGF Antibody Blocking Peptide - LS-E62 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FGF2 / Basic FGF Blocking Peptide - LS-E7990 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

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